Last edited by Kilmaran
Friday, April 17, 2020 | History

2 edition of Anthracyclines found in the catalog.

Anthracyclines

Anthracyclines

Current status and future developments

by

  • 389 Want to read
  • 39 Currently reading

Published by Masson Pub. USA .
Written in English

    Subjects:
  • Congresses,
  • Anthracyclines,
  • Testing,
  • Cancer,
  • Antibiotics, Antineoplastic,
  • Chemotherapy

  • The Physical Object
    FormatPaperback
    Number of Pages214
    ID Numbers
    Open LibraryOL8235309M
    ISBN 100893521884
    ISBN 109780893521882


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Anthracyclines Download PDF EPUB FB2

Anthracyclines have a chromophore moiety that has an intercalating function and inserts between adjacent base pairs of DNA when localized to the nucleus of the cell; this inhibits DNA and RNA synthesis, especially in highly replicating cells blocking cell division. This book is distributed under the terms of the Creative Commons Attribution.

Anthracyclines, Anti-Aromatase Agents, and COX-2 Inhibitors in Breast Cancer Therapy: A Critical Appraisal By Key Opinion Leaders on *FREE* shipping on qualifying offers. Anthracyclines are a class of potent and widely used cytotoxic drugs, derived from antibiotics that inhibit DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand.

From: Anthracyclines book of Clinical Neurology, Download as PDF. About this page. Nicholas R. Bachur, in Encyclopedia of Cancer (Second Edition),   Anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin) are among the most potent chemotherapeutic agents and have truly revolutionized the management of childhood cancer.

They form the backbone of chemotherapy regimens used to treat childhood acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin lymphoma, Ewing sarcoma, osteosarcoma, and Cited by: Kuffel MJ, Reid JM, Ames MM. Anthracyclines and their C metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture.

Cancer Chemother Pharmacol ; 51– PubMed CrossRef Google Scholar. Anthracycline hypersensitivity: Patients with previous anaphylactic reactions following administration of anthracyclines Hepatic disease: Patients with severe hepatic disease, defined as Child-Pugh class C or serum bilirubin greater than 5 mg/ml – dosage adjustments are necessary for patients with mild to moderate hepatic disease.

In Cancer and the Heart, third edition, Dr. Ewer and colleagues at MD Anderson are joined by national and international authorities who contributed to the 28 chapters of this various authors present their insights into the effects of anticancer drugs and radiation treatment on Price: $   The following are summary points from this review of anthracycline cardiotoxicity mechanisms, monitoring, and prevention: Cancers responsive to anthracyclines include carcinoma (breast, small cell lung, bladder, esophagus, stomach, liver, and thyroid), Anthracyclines book (AML and ALL), lymphomas (Hodgkin’s and non-Hodgkin’s, cutaneous T-cell lymphoma), and sarcoma (osteogenic.

Daunorubicin was the first anthracycline isolated, a natural product isolated from the actinobacteria Streptomyces peucetius. Anthracyclines book was identified in by both Italian and French groups [7, 38].

Daunorubicin was the first anthracycline isolated, a natural product isolated from the actinobacteria Streptomyces peucetius. Part of the Cancer Growth and Progression book series (CAGP, volume 13) Abstract. derivates [6]. Although a vast number of analogues were synthesized after these initial discoveries, only two other anthracyclines Cited by: Anthracyclines have a severe adverse effect in cardiac function.

Same here, Anthracyclines book has cardiotoxicity even in single use and also should lead to exacerbation of anthracycline-induced cardiotoxicity. Concurrent administration of anthracycline and trastuzumab is dangerous, but sequential administration is also dangerous.

We should carefully design trastuzumab-containing regimens based Author: Naoki Watanabe, Takeshi Yuasa, Ken Shimada. Oxidation of anthracyclines leads to their degradation and inactivation.

This process is carried out by peroxidases in the presence of a catalytic cofactor, a good peroxidase substrate. Here, we investigated the effect of salicylic acid, a commonly used anti-inflammatory and analgesic agent, on the peroxidative metabolism of anthracyclines.

We report that at pharmacologically relevant. Several liposomal anthracyclines currently are available, including liposomal daunorubicin, nonpegylated liposomal doxorubicin, and pegylated liposomal doxorubicin. Although these agents were developed with the purpose of maintaining antitumor efficacy and reducing Anthracyclines book, it should be noted that the extent of cardiac safety varies by Cited by: Anthracyclines work by damaging cancer cells’ genes and interfering with their reproduction.

Like all Anthracyclines book medicines, anthracyclines may cause serious side effects, including heart damage, which can lead to heart failure.

The risk of heart problems can be higher when other treatments that may cause heart damage – Herceptin (chemical. The clinical use of anthracyclines like doxorubicin and daunorubicin can be viewed as a sort of double-edged sword.

On the one hand, anthracyclines play an undisputed key role in the treatment of many neoplastic diseases; on the other hand, chronic administration of anthracyclines induces cardiomyopathy and congestive heart failure usually refractory to common medications.

This is a list of chemotherapeutic agents, also known as cytotoxic agents, that are known to be of use in chemotherapy for list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection.

ANTHRACYCLINES. Anthracyclines are antibiotics that promote DNA damage. This group, which includes doxorubicin, is found in the soil of Streptomyces bacteria. Anthracyclines were introduced in the s and remain a major component of many chemotherapy regimens, including those for lymphomas, breast cancer, and small cell lung by: Anthracyclines.

Florencio Zaragoza Dörwald. Lonza AG, Rottenstrasse 6, Visp, Switzerland. Search for more papers by this author. Book Author(s): Dr. Florencio Zaragoza Dörwald. Lonza AG, Rottenstrasse 6, Visp, Switzerland.

Search for more papers by this author. The NCI Dictionary of Cancer Terms features 8, terms related to cancer and medicine. We offer a widget that you can add to your website to let users look up cancer-related terms.

Get NCI’s Dictionary of Cancer Terms Widget. Anthracycline cardiotoxicity remains a serious problem in pediatric and adult cancer survivors. This chapter discusses the involvement of multiple cardiac cell types in the pathogenesis of the onset and progression of doxorubicin cardiotoxicity.

In addition to cardiomyocytes, considered the classical cellular target, the role of cardiac fibroblasts and vascular cells together with progenitor Author: Antonella De Angelis, Donato Cappetta, Liberato Berrino, Konrad Urbanek.

ANTHRACYCLINES - SIDE EFFECTS AND LATE EFFECTS Cardiotoxicity. The anthracyclines, particularly doxorubicin (generic name Adriamycin), are known to cause heart failure in a subset of patients in a dose-dependent manner. In other words, the higher the cumulative dose, the larger number of patients who experience this effect.

Anthracycline-File Size: 46KB. Chapter 2 examines anthracyclines, trastuzumab, and cardiomyopathy. Chapter 3 offers information on targeted therapies and cardiomyopathy, and Chapter 4 examines radiation therapy and the heart.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Sarah Cuddy, John D. Groarke, in Essential Echocardiography, Anthracyclines. Anthracyclines are highly effective chemotherapies used in the treatment of many solid and hematological malignancies.

Cardinale et al. reported an overall incidence of 9% of cardiotoxicity (defined as a decrease in LVEF by >10% from baseline and absolute LVEF. For patients receiving anthracyclines and/or trastuzumab after baseline clinical evaluation and heart echo, routine clinical follow-ups and heart echos are recommended every 3 months for the first year of therapy.

41 For anthracyclines in particular, a repeat echo is also advisable at a cumulative dose of mg/m 2 or even earlier if clinical Cited by: 3. This book describes the effect of these drugs on intracellular Fe trafficking and distribution in both neoplastic and myocardial cells.

The anthracycline, doxorubicin (DOX) and its analogues interfere with tumor and myocardial cell Fe metabolism by decreasing the RNA-binding activity of the iron-regulatory proteins (IRPs), that are involved in. The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species.

The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists Book Edition: 1. Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL).

Recent studies have shown that anthracyclines may induce toxicity in the vascular endothelium. Anthracycline: A member of a family of chemotherapy drugs that are also antibiotics.

The anthracyclines act to prevent cell division by disrupting the structure of the DNA and terminate its function. They do so in two ways: (1) they intercalate into the base pairs in the DNA minor grooves; and (2) they cause free radical damage of the ribose in the DNA.

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2, entries, around authors provide a complete.

Click on the book chapter title to read more. Pharmacologic:anthracyclines PregnancyCategoryD Indications AIDS-related Kaposi’s sarcoma (KS) in patients who cannot tolerate or fail conven-tional therapy.

Ovarian carcinoma. Multiple myeloma with bortezomib in patients who have not previously received bortezomib and File Size: KB. Anthracyclines. Anthracyclines are used to treat leukemia, breast cancer, ovarian cancer, lung cancer, neuroblastoma, soft tissue sarcoma, Hodgkin's disease, Kaposi's sarcoma, and multiple myeloma.

They work by stopping or slowing down the growth of cancer cells. The camptothecins are inhibitors of topo 1 with broad activity against epithelial cancers. Camptothecin was isolated from the Chinese tree Camptotheca acuminata in and had potent antitumor effects in animal systems.

Topotecan (Hycamptin) and irinotecan (Camptosar), two synthetic agents in this class, have been subsequently approved for clinical use in the United States.

title = "WP, a novel anthracycline with enhanced proapoptotic and antileukemic activity", abstract = "Background. MDR1 or MRP1 drug resistance mechanisms seriously limit the efficacy of anthracyclines such as doxombicin, in the treatment of acute myeloid leukemia (AML).Cited by: Anthracyclines and Heart Failure Douglas B.

Sawyer, M.D., Ph.D. Since their discovery more than 50 years ago, anthracyclines have become the mainstay for the treatment of many cancers. However, anthracy-clines are associated with a risk of heart failure, with the risk proportionate to the cumulative exposure; cardiac injury appears to occur withCited by: The Linked Data Service provides access to commonly found standards and vocabularies promulgated by the Library of Congress.

This includes data values and the controlled vocabularies that house them. Datasets available include LCSH, BIBFRAME, LC Name Authorities, LC Classification, MARC codes, PREMIS vocabularies, ISO language codes, and more.

Anthracyclines damage DNA through different mechanisms, including topoisomerase II poisoning. Anthracyclines are mutagenic and carcinogenic in vitro and in animals [ 8 ].

Since topoisomerase IIα is overexpressed in rapidly growing tissues [ 9 ], poisoning topoisomerase II is a potential source of major damage for the embryo, or to a lesser Cited by: anthracycline: [ an″thrah-si´klēn ] a class of antibiotics isolated from cultures of Streptomyces peucetius; it includes the antineoplastic agents daunorubicin and doxorubicin.

The use of these drugs is limited by a chronic, cumulative, dose-related toxicity resulting in irreversible congestive heart failure. Anthracycline. For daunorubicin. Studies in anthracycline synthesis Steven Rodney Crowley Iowa State University Follow this and additional works at: Part of the Organic Chemistry Commons This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital.

Still valid and useful after up to a decade, this series presents critical reviews of the present position and future trends in modern chemical research. It is made up of short and concise reports on chemistry, each written by the world renowned experts.anthracycline [an″thrah-si´klēn] a class of antibiotics isolated from cultures of Streptomyces peucetius; it includes the antineoplastic agentsdaunorubicin and doxorubicin.

The use of these drugs is limited by a chronic, cumulative, dose-related toxicity resulting in irreversible congestive heart failure. Anthracycline. For daunorubicin, R1 = -CH3. What is an Anthracycline? Chemotherapy is used in the treatment of cancer, and involves aggressively attacking cells to prevent a cancer from spreading and encouraging it to shrink.

Anthracycline is a cancer treatment, although over time it can cause cardiac damage in children.